GREAD Case Study I:Multiple Sclerosis
- Patient outcomes for MS
- Short term: relapse
- Long term: disability (EDSS)
- Treatment options
- Disease modifying treatments (DMTs)
- High-efficacy (HE) vs standard-efficacy (SE) classified mostly by relapse outcomes
- SE is established for 1st line
- What about 2nd line?
- Rotate to another SE
- Escalate to HE
GREAD Case Study II: Rheumatoid Arthritis
- Patient outcomes for MS
- Binary: remission
- Quantitative: disease activity score (DAS)
- Treatment options
- Methotrexate established for 1st line
- Add Tumor Necrosis Factor inhibitor (TNFi) for 2nd line
- What about 3rd line?
- Cycling to another TNFi
- Swapping to other biologics
